The three remaining Genero Adran Trophy round of 16 ties, which were postponed in the lead up to Christmas, will take place this weekend.
Pwllheli face a difficult task of welcoming Cardiff City to the Rec, who have had a positive season so far in the top flight.
Sunday’s hosts are currently sitting in fifth position after their opening six fixtures, having recorded two wins and four losses.
In this competition so far, Pwllheli have secured victories over Wrexham, Airbus UK Broughton and Llanfair United.
Visitors Cardiff City will be opening their Genero Adran Trophy campaign with their first game of 2022.
The Bluebirds ended last calendar year with a tough 4-1 loss to title rivals Cardiff Met, but will be looking to get back to winning ways in the cup competition.
With the draw for the next round of the competition already made, the winners will go on to face Barry Town United of the Genero Adran Premier.
Cardiff Met play host to Llandudno, who have set the Genero Adran North alight so far this campaign, at Cyncoed Campus on Sunday.
The Archers have impressed once again this campaign despite losing key player Chloe O’Connor in the summer, with Yzzy Taylor's side currently sitting second in the table.
Llandudno have recorded six wins from their opening eight fixtures, ensuring they sit top of the table.
With both sides enjoying a good run of results so far this season, it’s set to be an entertaining clash in the Welsh capital.
The game of the weekend will be played at the USW Sport Park as Pontypridd Town face Abergavenny.
Fern Burrage-Male’s side narrowly missed out on a place in the top four on the final day of Phase One, losing out to the impressive Aberystwyth Town.
Despite facing a side from the league below, a clash against Abergavenny will be a big test, as the Pennies have been remarkable this campaign.
Craig Morgan-Hill’s side have gained a five-point lead at the top of the Genero Adran South, leading rivals Cascade, Briton Ferry Llansawel and Cardiff Bluebelles.
Abergavenny have dropped points just once this season, with their hopes of returning to the top flight looking strong.
With both sides evenly matched, it will be a fascinating tie at the USW Sport Park.